Prestorage Leukocyte Reduction with In-Line Filtration of Whole Blood (1)
Leukocyte reduction filters components appears to be an effective method to reduce leukocyte-induced adverse reactions and other complications. To determine whether it is better to filter whole blood before component separation, we compared the efficiency of in-line filtration of whole blood with that of postseparation filtration.
Blood was collected from normal, healthy donors into either regular triple-bag containers or into whole-blood integral-filter container systems. We then compared the in vitro storage values of leukocyte-depleted red blood cell concentrates (RBCC) kept at 4 °C, and plasma frozen for 1 year with nonfiltered blood components as control.
