Prestorage Leukocyte Depletion with In-Line Filtration of Whole Blood （2）
All filtered RCCs and plasma units (CF and WBF) had white blood cell contaminations <1′105 per unit. Platelets were reduced in all filtered components: 95% in plasma and 99% in RCCs. Fresh-frozen plasma (FFP) prepared by CF and WBF had normal amounts of factors V, VIII, von Willebrand factor and thrombin-antithrombin-III complexes, whereas platelet factor 4 (PF-4) was slightly increased in FFP prepared by WBF. RCCs and plasma units prepared from filtered whole blood (n = 20) had a significantly greater volume (RCC: 288±19 ml; plasma: 274±20 ml) than conventionally prepared (n = 20) and filtered products (RCC: 257±19 ml, plasma: 259±19 ml).
For early filtration of blood components, WBF prior to component preparation seems to offer an interesting technique for obtaining a leukocyte-depleted RCC and FFP.
