Leukocyte Reduction Filters Associated with Platelet Transfusions to Converting
Leukocyte reduction filters associated with platelet transfusions to converting enzyme inhibitors. Background and Objectives is to determine the cause of hypotensive reactions associated with platelet transfusions in coronary artery bypass surgery patients. Platelet transfusion reactions that occurred during a 3-month period were retrospectively reviewed.
The results will eighteen transfusion reactions occurred in 16 patients. Sixteen of the reactions were hypotensive, and occurred in 14 patients transfused with platelets through negatively charged bedside leukocyte reduction filters. All 14 patients had received angiotensin - converting enzyme (ACE) inhibitors prior to transfusion. Preliminary findings suggest a new type of transfusion reaction associated with the use of negatively charged leukocyte reduction filters during platelet transfusions to patients on ACE inhibitors.
