Clinical Efficacy of Phase Leukocyte Reduction Filters in High-risk Patients (2)
Leukocyte reduction filters and strategic filtration groups demonstrated significant differences. Demonstrated well preserved myocardium in double filter group. Brain natriuretic peptide levels in double filter group were significantly lower with respect to group and control. Matrixmetallopeptidase and dimer levels in double filter group were significantly lower.Two-phase leukofiltration is associated with some compound benefit over continuous deployment in high-risk patients. A larger more powerful study than this pilot one is warranted for further evaluation. Minor histocompatibility antigens on transfused leukoreduced units of red blood cells induce bone marrow transplant rejection in a mouse model.
